Ivermectin+Rafoxanide Injection / Rafomac®

What is Ivermectin+Rafoxanide?

Ivermectin, Rafoxanide

Ivermectin is a broad-spectrum antiparasitic that is effective against internal and external parasites in cattle, sheep, and camels.it is one of the substances of the avermectin family, characterized by high effectiveness and safety, as it affects the nervous system of parasites (worms and insects), causing their paralysis and elimination. It is well tolerated because it does not easily penetrate the central nervous system of these animals.
Rafoxanide: (halogenated salicylamide Group ) effective anthelmintic against flatworms (hepatoprotective) and some roundworms (roundworms/nematodes) and larval stages of the nose bot fly in sheep.
Its good absorption and slow excretion make it bind to the blood plasma for a long time and, therefore, acquire a prolonged (Half-Life) period, which leads to effectiveness and therapeutic effects against the immature stages of worms.
 The method of its action is based on the fact that it is a  (Proton-ionophore compound, where the stalactites (cations) resulting from the chemical decomposition of the active substance penetrate the cell wall of the worms and then decouple the oxidative phosphorylation process inside the mitochondria of the worms, which leads to their death.

 Indications :

It is used to control the following parasites :

• gastric and intestinal roundworms (mature and larval stages): osteria ostertagii, osteria lirata, harmonious place, trichostrongylus Axei, trichostrongylus colibriformis, coopers oncophora coopers punctate, coopers pectinate, bunostomum phlebotomy, esophagostomy radiatum, Strongyloides papillosus, nematodes Helvetians, nematodes spathiger and Trichuris species.
• lungworms: dictyocaulus viviparous (mature and larval stages).
• It is used for the treatment of mature and immature liver flukes and blood-sucking worms such as hormones, bunostomum, andesophagostomym
• other roundworms: from the types of chalazia (eyeworms) and para filaria viola mature stages).
• cattle grub: hypoderma bovis, hypoderma lineatum (larval phases).
• screw worm fly: Chrysomya bezziana (larval phases).
• lice: linognathus vituli, Haematopinus   eurysternus, solenopotes capillatus And biting lice: Damalinia bovis (mature stages).
• scabies: psoroptes bovis, psoroptes Ovis, Sarcoptes scabiei And Sorbus communis Ovis (mature stages).
• tick: ornithodoros savignyi (mature stages).
• nasal bot: oestrus Ovis (larval phases). In cattle, sheep, goats, camels

Contra-indications: Hypersensitivity to the active substances.

Dosage and Administration :

Via subcutaneous injection only.

• cattle and camels: 1 ml /50 kg of animal weight
• It is recommended to give a second dose 15 days after the first dose
• Sheep and goats: 0.5 ml / 25 kg  of animal weight

It is recommended to provide a second dose 7 days after the first dose

Precautions :

• Do not smoke or eat during administration of the product.
• Wash hands after injection.
• Keep the product out of the reach of children.
• Do not administer concurrently with organophosphorus compounds within 15 days before or after treatment.
• Hypersensitivity to the active ingredients.

Side Effects : 

Some animals experience some pain after injection or some slight superficial swelling at the injection site, but these phenomena are temporary and resolve after a short time.