Sulfadiazine Sodium + Trimethoprim Injection is a combination medicine indicated for bacterial infections.
Sulfadiazine Sodium + Trimethoprim Injection / Newten®
What is Sulfadiazine Sodium + Trimethoprim?
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Antibiotic |
Therapeutic Class |
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Cat , Cow ,Dog , Horse , Pig |
Target Species |
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200mg Sulfadiazine Sodium+ 40mg Trimethoprim |
Active Ingredients |
Sulfadiazine Sodium +Trimethoprim
Sulfadiazine Sodium + Trimethoprim Injection is an antibiotic/antimicrobial combination drug used to treat infections in cats , dogs , horses , cows , and pigs. This medicine is indicated for the treatment of certain gastrointestinal, respiratory, and urinary tract infections caused by susceptible microorganisms.
This injectable solution contains the active ingredients sulfadiazine and trimethoprim. Sulfadiazine is classified as a sulfonamide antibiotic. It displays action against most gram-positive and many gram-negative bacteria. It works by inhibiting folic acid synthesis within the bacteria. Trimethoprim is classified as an antibiotic and folate synthesis inhibitor.
This drug is well absorbed after administration and reaches high therapeutic plasma concentrations. It is well distributed into body tissues and fluid and penetrates the respiratory tract, gastrointestinal tissues, urogenital tract, and synovial fluids. Trimethoprim binds to proteins (40-70%), and sulfadiazine has a lower binding affinity (20-30%). This drug is
metabolized in the liver and undergoes acetylation and conjugation (sulfadiazine), and trimethoprim is metabolized into several inactive metabolites.
This antibiotic is excreted via the kidneys and the half-life varies (between 5 and 12 hours).
Sulfadiazine inhibits the bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). This blocks the production of folic acid which is needed for bacterial growth and replication. Trimethoprim inhibits the bacterial dihydrofolate reductase which is needed for the conversion of dihydrofolic acid to tetrahydrofolic acid.
The combination shows a broad range of activity against gram-positive and gram-negative bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus, and Streptococcus.
It is important to note that Sulfadiazine + Trimethoprim Injection is for veterinary purposes only.
Indications :
Dosage and Administration :
Administer by intramuscular injection .
Dosage: 1 ml per 10 kg body weight daily.
Precautions :
Do NOT use Sulfadiazine Sodium + Trimethoprim Injection for an animal that:
Treatment with this drug should be administered with caution for an animal that is dehydrated. If the owners notice any side effects, they should report it immediately to a veterinary professional.
The dosage should be carefully selected in animals with impaired liver or kidney function. Pregnant and lactating animals should be treated only if the benefits outweigh the risks.
Owners should inform the veterinarians about any drugs or supplements that the animal is taking at the moment. They should also be aware of the animal's previous medical history.
Side Effects :
As with all pharmaceuticals, some unwanted effects can occur from the use of Sulfadiazine Sodium + Trimethoprim Injection.
Some common side effects may include but are not limited to: temporary swelling near injection site Serious side effects may include:
Sulfadiazine Sodium + Trimethoprim Injection is mainly used for treating acute, subacute, or chronic bacterial infections in cattle, pigs, horses, and companion animals (cats and dogs). It is used for treating the following bacteria:
It is used to treat infections such as:
It is recommended for horses, cows, and pigs. It's also used to treat companion animals like dogs and cats.
This medication has been manufactured as a liquid, which is packaged in a vial. It is intended to be administered by intramuscular (IM), intravenous (IV), and subcutaneous (SC) injection. Sulfadiazine Sodium + Trimethoprim Injection is intended for veterinary use only.
In cattle and pigs, it should be administered intramuscularly or by slow intravenous injection. In horses, it should be administered only by slow intravenous injection. In companion animals, it should be only administered by a subcutaneous injection.
This antimicrobial drug is used for treating various bacterial infections that are susceptible to the drug.
This antibiotic can help relieve the signs of pneumonia, pleuropneumonia, and bacterial bronchitis in horses, as well as other bacterial infections that affect other tracts. Studies show that trimethoprim-sulfadiazine can help in the treatment process of Streptococcus equi subsp. zooepidemicus. This study included 119 horses, and 58% of them had a positive clinical response.
It depends on the severity of the health issue. In some mild cases, only this antibiotic can improve the overall health status of the animal, but very often, other drugs and supplements might be included.
It should be used only if the benefits outweigh the risks. The veterinarian should examine the animal before adding any antibiotic or other drug to a pregnant or lactating anima
This antibiotic might interact with amantadine, antacids, cyclosporines, or potassium supplements. Owners should inform the veterinarians about any drugs the animal is taking at the moment.
This medication should be stored in a dark, dry location under 30°C. The vial should be sealed tightly.
The withdrawal time is 7-15 days for meat.
The usual dose is 15mg/kg, given once or twice per day. The duration of treatment should be 2-3 consecutive days. It should be administered intramuscularly or by slow intravenous injection.
The usual dose is 15mg/kg, given once or twice per day. It should be administered only by slow intravenous injection.
The usual dose is 1 ml per 8kg of body weight, given once or twice per day. It should be administered only by a subcutaneous injection.
Refer to a veterinary doctor or pharmacist for guidelines on dosage.
