Dimapen_100ml

Procaine Penicillin and Dihydrostreptomycin for Injaction / Dimapen® 

What is Procaine Penicillin and Dihydrostreptomycin?

Procaine Penicillin and Dihydrostreptomycin

DIMAPEN Suspension for Injection is a broad-spectrum veterinary antibiotic combining procaine penicillin and dihydrostreptomycin, providing effective treatment against a wide range of gram-positive and gram-negative bacteria. It is used to manage acute and systemic infections, as well as to control secondary bacterial complications following viral illnesses.

This injectable suspension offers a synergistic effect:

• Penicillin : bactericidal action via inhibition of bacterial cell-wall synthesis.
• Dihydrostreptomycin: an aminoglycoside that inhibits protein synthesis at the 30S ribosomal subunit.

Together they deliver rapid, reliable action in food-producing animals and horses

Indications :

procaine penicillin and dihydrostreptomycin are indicated for the treatment of systemic infections caused by organisms sensitive to penicillin and/or streptomycin, including:

• Erysipelothrix rhusiopathiae
• Arcanobacterium pyogenes
• Klebsiella pneumoniae
• Listeria spp
• Mannheimia haemolytica
• Pasteurella multocida
• Staphylococcus spp (non-penicillinase producing)
• Streptococcus spp
• Salmonella spp
• It is also used to control secondary bacterial infections complicating viral diseases.

Suspension for Injection is a broad-spectrum antibiotic combination used to treat systemic and localised bacterial infections in several animal species, including cattle, horses, sheep, and pigs.

Dosage and Administration :              

Shake well before use to ensure uniform suspension. Deep intramuscular injection only.

1 mL per 25 kg bodyweight (Equivalent to approximately 8 mg/kg procaine penicillin + 10 mg/kg dihydrostreptomycin.)

Treatment duration: Administer once daily for up to 3 consecutive days, or as directed by the veterinarian based on clinical response.

Precautions :

Do NOT use  Dimapen in animals that:

• animals that Have known hypersensitivity to penicillins or aminoglycosides, Have renal impairment (use with caution)
• People administering the product should avoid Accidental self-injection Contact if previously sensitized to β-lactams
• Seek medical attention if allergic symptoms occur.
• Do NOT combine with Tetracyclines and Other aminoglycosides

Side Effects :

Dimapen is generally well tolerated; however, some animals may exhibit mild to rare adverse reactions:

1- Hypersensitivity Reactions (Allergic Reactions) : May occur in animals sensitive to penicillins oraminoglycosides.  Signs include:

• Swelling at the injection site
• Urticaria (hives)
• Respiratory difficulty
• Collapse (very rare, severe anaphylaxis)
•  Immediate veterinary intervention is required in severe cases.

2- Local Reactions at Injection Site : Mild, transient swelling may occur—especially in horses, Typically resolves within a short period without treatment.

3- Systemic Reactions in Pigs (Rare) : Pigs may occasionally show Fever, Vomiting, Shivering and Incoordination.

4- Gastrointestinal + Renal Considerations : Because dihydrostreptomycin is an aminoglycoside Use caution in animals with compromised kidney function, as accumulation may increase toxicity risk. Toxic effects are rare when dosage guidelines are followed.

5- Effects During Pregnancy (Pigs) : Pregnant sows and gilts may rarely exhibit vulval discharge that could be associated with abortion. Use only under veterinary supervision during pregnancy.